An Unbiased View of pkrrating
The interfacial residues are highly conserved amongst eIF2α kinases and mutagenesis implicates the BTB dimer in PKR function18. FRET measurements show the kinase domains dimerize when PKR binds to activating dsRNAs19. These observations assistance a model the place activating RNA serves to be a scaffold to bind multiple PKR monomers, increasing th